Primary kidney tumor. Metastatic disease newly diagnosed RCC with metastatic disease. R n=58 n=30 ilixadencel. 2 weeks control – no ilixadencel injections.

These data support the continued clinical development of ilixadencel as an immune primer in RCC and other solid tumors, to provide cancer 

A combination of ilixadencel plus sunitinib has shown a complete tumour response in patients with metastatic renal cell carcinoma (RCC) in a recent phase 2 clinical trial.. Ilixadencel is an off-the-shelf immune primer for the treatment of solid tumours. The clinical trial assessed the effectiveness of combining ilixadencel with sunitinib in 88 untreated patients with intermediate- or poor 2020-02-10 A phase 2 clinical trial with a new treatment called ilixadencel in combination with sunitinib has shown to improve overall survival in newly diagnosed patients with metastatic renal cell carcinoma (RCC). People given the combination treatment lived 10 months longer than those on sunitinib alone, suggesting that ilixadencel aids survival in these patients. In May 2020, ilixadencel was granted a Regenerative Medicine Advanced Therapy designation from the FDA for use in patients with RCC. A few months later, in December 2020, the agent received a fast track designation for use in the treatment of patients with GIST. The FDA awarded ilixadencel RMAT based on the results of the previously announced Phase II MERECA clinical trial. The trial evaluated the efficacy and safety of ilixadencel combined with the targeted anticancer drug Sutent (common name: sunitinib, sunitinib; developed by Pfizer) in the first-line treatment of patients with newly diagnosed metastatic renal cell carcinoma (mRCC).

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Upon intratumoral injection of ilixadencel, the dendritic cells (DCs) release  Sep 17, 2020 advanced renal cell carcinoma (RCC) patients in the CheckMate-214 treated with the combination of ilixadencel and anti-CTLA4 showed a  2020年5月12日 ilixadencel的活性成分是来源于健康献血者的树突状细胞（DC），这些 支持了 ilixadencel作为一种免疫触发剂在肾细胞癌（RCC）和其他实体  In addition to MCC, UC and RCC, these cancers include breast, was with Immunicum to investigate avelumab in combination with ilixadencel, an off-the- shelf,  Nov 10, 2015 Clinical studies have used systemic administration of IL‐12 in patients with melanoma, RCC and colon cancer, unfortunately this approach was  There has been no clinically useful diagnostic or prognostic biomarker for renal cell carcinoma (RCC). Serum γ-glutamyltransferase (GGT) activity has been  2020年5月，美国FDA授予ilixadencel治疗转移性肾细胞癌（RCC）的再生医学 先进疗法（RMAT）资格。在2020年12月，FDA授予ilixadencel治疗GIST的快速  2020年5月，美国FDA授予ilixadencel治疗转移性肾细胞癌（RCC）的再生医学 先进疗法（RMAT）资格。在2020年12月，FDA授予ilixadencel治疗GIST的快速  Feb 1, 2021 Phase II study of ilixadencel + pre- and post-nephrectomy sunitinib then TG4010 + IFNα2a + IL2 in patients with MUC1-positive RCC (n = 37)  Dec 8, 2020 Ilixadencel tested in the ongoing multi-indication Phase Ib/II ILIAD study of breakthrough combination with ilixadencel and CTLA4 in RCC  the Phase II MERECA trial with ilixadencel delivered a positive surprise. newly diagnosed and had metastatic renal cell carcinoma (RCC),  ODD, från EMA för ilixadencel för behandling av gastrointestinal för behandling av patienter med metastaserad njurcancer (RCC). Ilixadencel: unique off-the-shelf cell therapy that kick-starts immune response.

#wewontrest #cancer #CAR-T @BCF_1982 #RCC #Nätverket mot cancer Se och läs Immunicums Ilixadencel blir skräddarsytt i patientens  Immunicums ledande produkt ilixadencel utnyttjar den unika och kritiska mation om de pågående studierna inom RCC och GIST, se avsnittet  De prekliniska resultaten visar hur ilixadencel genererar komplementära immunologiska Njurcancer (RCC) Rekryteringen har slutförts till den pågående  Ilixadencel är en off-the shelf - produkt framtagen från friska allogena Fas II Fas III Ilixadencel IM-201 Njure (RCC) Ilixadencel IM-102 Lever (HCC) Ilixadencel  Cancercentrum (RCC). Du kan också I studierna hittills har ilixadencels säkerhetsprofil olika cancerformer där ilixadencel skulle kunna  Bernie Maddog har fått RCC, Immunicum AB, 20-02-06 12:32 Detta pga alla nya potentiella behandlingar så det är orimligt att Ilixadencel når  Fas II delen av ILIAD, där man utvärderar effekt av ilixadencel i med BMS nivolumab + ipilimumab i RCC innan man tar ställning till fas III. Bolaget har även en pågående fas II-studie inom njurcancer (RCC) kallad Det intressantaste med verkningsmekanismen av ilixadencel är att  att cancerimmunaktiveraren ilixadencel kombinerats med standardläkemedel Regionala cancercentrums (RCC) samverkansgrupp beslöt vid sitt möte 18  The addition of the off-the-shelf cancer immune primer ilixadencel to sunitinib (Sutent) trended toward a benefit in overall survival (OS) compared with sunitinib alone as a first-line treatment FDA Grants RMAT Designation to Ilixadencel in Metastatic RCC "We are very excited to have received the RMAT designation for ilixadencel in kidney cancer as it recognizes both the potential of our novel therapeutic approach as well as the clear need for viable therapies to address this difficult-to-treat disease." The active ingredient in ilixadencel is activated allogeneic dendritic cells, which are derived from healthy blood donors.

To-date ilixadencel has been tested in a range of clinical trials in various solid tumor indications including metastatic Renal Cell Carcinoma (mRCC), 

Portions of this data were previously communicated on August 29, 2019. Immunicum has announced an update on its corporate and clinical development strategy.

According to the latest (July) follow-up update from the MERECA trial (ilixadencel in renal cell carcinoma; RCC), the mOS was reached at 25.3 months in the sunitinib (control) group, while in the ilixadencel plus sunitinib group the mOS has not been reached yet. In the ilixadencel group, 43% of patients were still alive, vs 33% in the control group.

Recruitment in this trial was completed in early January 2018. 7 maj, 2020 Immunicum’s lead candidate, ilixadencel, just got a big boost in its development by being granted regenerative medicine advanced therapy designation by the FDA. The regulatory measure is designed to get promising new cell or gene therapies to market faster, and a clear signal that the FDA sees high potential in ilixadencel.

Designation (FTD) för ilixadencel för behandling av den sällsynta sjukdomen gastrointestinal stromalcellstumör. (GIST). Immunicum erhöll Fast Track Designation från FDA för ilixadencel för för njurcancer (RCC) och Fast Track Designation (FTD) för ilixadencel  A randomized phase II study with ilixadencel, a cell-based immune primer, plus sunitinib versus sunitinib alone in synchronous metastatic renal cell carcinoma.
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“With the information presented today at the corporate update event, we aim to provide an overview of our position as a cell therapy company, discuss strategic opportunities we intend to leverage and confirm our long-term mission for Immunicum,” commented Sven Rohmann, CEO of Immunicum. Ilixadencel-Sunitinib Combo Improves Response In Certain Patients With Metastatic RCC In Phase II Trial wb.md/38xBsq0 Eftersom ilixadencel har uppnått Proof of Concept i RCC i kombination med sunitinib är nästa kritiska steg att identifiera rätt väg att påskynda utvecklingen av ilixadencel mot marknaden och i … For the biopharma industry investment, business development and competitive intelligence professionals who require information to support financing, partnering and licensing activities, BCIQ provides accurate information and context to support profitable and strategic decision making. Unlike other intelligence solutions, BCIQ exclusively supports the unique needs of the biopharma industry and Under 2020 beviljade den amerikanska läkemedelsmyndigheten FDA Immunicum Regenerative Medicine Advanced Therapy (RMAT) designation för njurcancer (RCC) och Fast Track Designation (FTD) för ilixadencel för behandling av den sällsynta sjukdomen gastrointestinal stromalcellstumör (GIST).

The Phase 1 portion of the trial ( NCT01525017) covered patients with newly diagnosed metastatic renal cell carcinoma, or mRCC. That is a cancer that has spread from the kidneys to other parts of the body.
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Ilixadencel is an off-the-shelf cancer immune primer developed for the treatment of solid tumors. The MERECA clinical trial evaluated the therapeutic impact of combining ilixadencel with sunitinib in advanced kidney cancer. For the study, 88 newly-diagnosed, intermediate- and poor-prognosis patients with metastatic RCC were enrolled.

Therapy (RMAT) designation for ilixadencel is in metastatic RCC. Det gör att vi övertygade om ilixadencels förmåga att främja mer långvariga och Njurcancer (RCC) - beprövad indikation, ny kombination REnal Cell CArcinoma) trial. The trial is investigating the safety and efficacy of Immunicum's lead drug candidate ilixadencel, formerly known  RCC (Nure) Fas I/II klar. Fas II (MERECA) pågår. I princip helt avgörande studie för ilixadencel. 90 patienter (60/30) nästan 30 studiecentra i  Produkt-lanseringar med ilixadencel, för RCC (njurcancer) och NSCLC (icke småcellig lungcancer) utgör 25 respektive 35 procent av värdet enligt Edison. Etiketter:Njurcancer, PATIENTÖVERSIKT, RCC i samverkan.